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- Title
Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection.
- Authors
Moya, Pedro; Miranda, Elena; Soriano-Irigaray, Leticia; Arroyo, Antonio; Aguilar, Maria-del-Mar; Bellón, Marta; Muñoz, Jose-Luis; Candela, Fernando; Calpena, Rafael; Bellón, Marta; Muñoz, Jose-Luis
- Abstract
<bold>Objective: </bold>To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice.<bold>Background: </bold>Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown.<bold>Methods: </bold>This study was a prospective, randomized trial with two parallel treatment groups receiving an immune-enhancing dietary supplement for 7 days before colorectal resection and 5 days postoperatively or dietary advice.<bold>Results: </bold>A total of 128 patients were randomized. At baseline, both groups were comparable with respect to age, sex, surgical risk, comorbidities, and analytical and nutritional parameters. The median postoperative LOS was 5 days and was not significantly different between the groups. Wound infection differed significantly between the groups (11.50 vs. 0.00 %, p = 0.006). No other differences between the groups were identified.<bold>Conclusions: </bold>The joint use of laparoscopy and supplementation with immunonutrients reduces surgical wound infection in patients undergoing colorectal surgery.<bold>Trial Registration: </bold>This study is registered with ClinicalTrial.gov : NCT0239396.
- Subjects
PROCTOLOGY; PERIOPERATIVE care; LAPAROSCOPIC surgery; DEATH rate; TREATMENT effectiveness; COLECTOMY; COLON tumors; COMPARATIVE studies; DIETARY supplements; ENTERAL feeding; LENGTH of stay in hospitals; LAPAROSCOPY; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RECTUM tumors; RESEARCH; SURGICAL site infections; EVALUATION research; RANDOMIZED controlled trials; PATIENT readmissions
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2016, Vol 30, Issue 11, p4946
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-016-4836-7