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- Title
Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway.
- Authors
Zhang, Yikai; Jia, Jing; Ding, Yi; Ma, Yongzheng; Shang, Peijin; Liu, Tianlong; Hui, Guangfei; Wang, Lin; Wang, Mingming; Zhu, Zhihui; Li, Yuwen; Wen, Aidong
- Abstract
Objectives The purpose of this study was to assess the gastroprotective properties of alpha-boswellic acid (α- BA), a pentacyclic triterpene compound from extracts of Frankincense. Methods The gastroprotection of α- BA was assessed with ethanol-induced gastric lesions model, by histopathological assessment and measuring gastric juice acidity ( pH), gastric wall mucus ( GWM), prostaglandins E2 ( PGE-2), membrane lipids peroxidation ( MDA), superoxide dismutase ( SOD) activity, catalase ( CAT) activity and amount of nitric oxide ( NO). The gastroprotective effects of α- BA through the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (Nrf2/ HO-1) anti-oxidative pathway were presented and measured by immunohistochemistry and Western blot. Key findings The results showed that α- BA reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner. The expression of both Nrf2 and HO-1 was significantly increased in the group treated with 200 mg/kg α- BA, which suggested that activation of the Nrf2/ HO-1 pathway might be critical in α- BA's prevention of gastric ulcers. Conclusions These findings demonstrate that α- BA decreases oxidative stress and that the Nrf2/ HO-1 pathway might play a role in the gastroprotective action of α- BA in ethanol-induced gastric injury in rats.
- Subjects
STOMACH injuries; HEME oxygenase; PHYSIOLOGICAL effects of antioxidants; ETHANOL; LIPID peroxidation (Biology); HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY
- Publication
Journal of Pharmacy & Pharmacology, 2016, Vol 68, Issue 4, p514
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12532