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- Title
Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice.
- Authors
Gershkovich, Pavel; Wasan, Ellen K.; Sivak, Olena; Li, Raymond; Xiaohua Zhu; Werbovetz, Karl A.; Tidwell, Richard R.; Clement, John G.; Thornton, Sheila J.; Wasan, Kishor M.
- Abstract
Objectives: To assess the impact of visceral leishmaniasis (VL) on the concentration of amphotericin B (AmB) recovered in the liver and spleen following either intravenous (AmBisome®) or oral (iCo-009) AmB administration to mice.
- Subjects
LEISHMANIASIS; PROTOZOAN diseases; AMPHOTERICIN B; IONOPHORES; HEMATOPOIETIC system; PHARMACOKINETICS; DISEASE progression
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 3, p535
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp465