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- Title
Control of extended-spectrum {beta}-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a childrens hospital by changing antimicrobial agent usage policy.
- Authors
Jina Lee; Hyunjoo Pai; Yun Kyung Kim; Nam Hee Kim; Byung Wook Eun; Hyoung Jin Kang; Kyoung Ho Park; Eun Hwa Choi; Hee Young Shin; Eui Chong Kim; Hoan Jong Lee; Hyo Seop Ahn
- Abstract
Objectives This ambidirectional intervention study was performed to examine the impact of a change in antibiotic policy on extended-spectrum β-lactamase (ESBL) prevalence in a childrens hospital with a high prevalence of ESBL production among Escherichia coli and Klebsiella pneumoniae. Methods The use of extended-spectrum cephalosporins was restricted and use of β-lactam/ β-lactamase inhibitor combinations was encouraged from 2002. All strains of E. coli and K. pneumoniae isolated from sterile body fluids from 1999 to 2005 were analysed for β-lactamase production and the prevalences of ESBL production were compared at three periods; pre-intervention (1999–2001), transitional period (2002–03) and post-intervention (2004–05). Results Comparing the pre- and post-intervention periods, overall piperacillin/tazobactam use increased from 2.2 to 108.0 days on antibiotics/1000 patient admission days/year (AD) (P for trend P for trend E. coli (n = 128) and K. pneumoniae (n = 124), the overall prevalence of ESBL producers decreased from 39.8% (41/103) to 22.8% (18/79) (P for trend = 0.018). This decreasing trend of ESBL production was more evident for K. pneumoniae (64.1% to 25.6%; P for trend E. coli (25.0% to 19.4%; P for trend = 0.514). The mortality rates of invasive disease caused by E. coli or K. pneumoniae remained unchanged. Conclusions The substitution of piperacillin/tazobactam for extended-spectrum cephalosporins successfully decreased the prevalence of ESBL production of K. pneumoniae and E. coli in an institute for children where ESBLs were endemic. The impact of change in antibiotic policy was more evident in K. pneumoniae than E. coli.
- Subjects
DRUG administration; BETA lactamases; ESCHERICHIA coli; KLEBSIELLA pneumoniae
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2007, Vol 60, Issue 3, p629
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkm225