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- Title
Cell signalling and the control of pre-mRNA splicing.
- Authors
Shin, Chanseok; Manley, James L.
- Abstract
The transcripts of most metazoan protein-coding genes are alternatively spliced, but the mechanisms that are involved in the control of splicing are not well understood. Recent evidence supports the potential of both extra- and intracellular signalling to the splicing machinery as a means of regulating gene expression, and indicates that this form of gene control is widespread and mechanistically complex. However, important questions about these pathways need to be answered before this method of post-transcriptional regulation can be fully appreciated.
- Subjects
GENETIC transcription; GENE expression; CELLS; GENETIC regulation; MOLECULAR genetics
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 9, p727
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1467