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- Title
Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice.
- Authors
Kitaichi, Yuji; Hashimoto, Ryota; Inoue, Takeshi; Abekawa, Tomohiro; Kakuta, Aya; Hattori, Satoko; Koyama, Tsukasa
- Abstract
ObjectiveGlycine regulates glutamatergic neurotransmission, and several papers have reported the relationship between glycine and schizophrenia. The dysbindin-1 (DTNBP1: dystrobrevin-binding protein 1) gene is related to glutamatergic neurotransmission and has been found to be a strong candidate gene for schizophrenia. In this study, we clarified the relationship between dysbindin, glutamate, and glycine with in vivo microdialysis methods.MethodsWe measured extracellular glycine and glutamate levels in the striatum of sandy (sdy) mice using in vivo microdialysis methods. Sdy mice express no dysbindin protein owing to a deletion in the dysbindin-1 gene. In addition, we measured changes in those amino acids after methamphetamine (METH) administration.ResultsThe basal levels of extracellular glycine and glutamate in the striatum of sdy mice were elevated. These extracellular glutamate levels decreased gradually after METH administration and were not subsequently different from those of wild-type mice.ConclusionsThese results suggest that dysbindin might modulate glycine and glutamate release in vivo.
- Subjects
GLYCINE; EXCITATORY amino acid agents; NEURAL transmission; SCHIZOPHRENIA; DYSBINDIN; METHAMPHETAMINE
- Publication
Acta Neuropsychiatrica, 2013, Vol 25, Issue 4, p215
- ISSN
0924-2708
- Publication type
Article
- DOI
10.1111/acn.12018