We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
GERANYLGERANYLACETONE REDUCES RADIATION-INDUCED DEGENERATION OF SEMINIFEROUS EPITHELIUM IN MICE.
- Authors
ŞERB, BOGDAN HORAŢIU; ORMENIŞAN, ALINA; PRELUCA, VLAD; CERNUŞCĂ-MIŢARIU, MIHAELA; MIŢARIU, MIHAI IOAN
- Abstract
Geranylgeranylacetone (GGA) has been shown to have cytoprotective effects against a variety of stressors via the induction of the heat shock response. In this study, male mice received GGA by gavage in doses of 250 mg/kg body weight (kg bw) and 1000 mg/kg bw daily for 5 days. The controls received the corresponding volume of vehicle. In the last day of treatment, all mice received a single dose of 4 gray (Gy) total body irradiation. Blood samples were collected before irradiation and at 2 and 8 days post-irradiation. The testes were removed after euthanasia, in the 8th day post-irradiation, for histological analysis. The results showed significant post-irradiation reduction of leukocyte and platelet counts, with no significant difference between treatment groups and controls. The seminiferous tubule proliferation status was significantly higher in mice treated with 1000 mg/kg bw GGA. In conclusion, GGA reduces radiation-induced degeneration of the seminiferous epithelium in mice.
- Subjects
CYTOPROTECTION; RADIATION-induced abnormalities; EPITHELIUM; HEAT shock factors; DEGENERATION (Pathology); PREVENTION
- Publication
Farmacia, 2016, Vol 64, Issue 4, p528
- ISSN
0014-8237
- Publication type
Article