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- Title
P-448: Efficacy on albuminuria and renal function, and tolerance of amlodipine, enalapril or both in renal transplant recipients : A multicentric randomized (PROBE) trial.
- Authors
Halimi, Jean-Michel; Al-Najjar, Azmi; Buchler, Matthias; Giraudeau, Bruno; Etienne, Isabelle; Marliere, Jocelyne; Nivet, Hubert; Bruyere, Franck; Lebranchu, Yvon
- Abstract
ACE inhibitors and calcium channel blockers are often associated in hypertensive renal transplant recipients. The effect on mean arterial pressure (MAP), albuminuria and creatinine clearance (CrCl) and tolerance of this association are unknown.Ninety-nine renal transplant recipients were randomized to receive amlodipine (A), enalapril (E) or both (AE) for 6 months (M6). MAP was measured with Dynamap®. Albuminuria (UAE) and CrCl were assessed on 24h-urine collections.At M6, the decrease in MAP was higher in group AE than the group A and E (M±SD : -15±15 vs -3±12 et -7±12 mmHg respectively, p=0.001). The decrease in UAE was higher in group E (-60.1%) and AE (-67.4%) than in group A (-21.8%), but was similar in group A and AE (A vs E : p=0.02, A vs AE : p=0.002, E vs AE : p=0.71). ClCr increased in group A (+15±31 ml/min, p=0.008), but remained stable in group E (-7.7±27.7 ml/min) and AE (-1.2±20.4 ml/min). The daily dose of CsA was lower (-21±32 mg/d, p<0.01) and the CsA blood levels higher (+18±35 mg/l, p=0.01) in group A, but these parameters remained unchanged in the other 2 groups. The prevalence of patients with leg edema was similar in group A and AE, whereas the prevalence of cough was similar in group E and AE.The association of A and E has no adverse effect on renal function, but it does not amplify the reduction of albuminuria obtained by E alone, and does not reduce the adverse reactions associated to A alone or E alone. There is an interaction between A and CsA which is modulated by E administration.This work received a grant from the ' Club des Jeunes Hypertensiologues ' and Tours Hospital (' Hopital Promoteur ').Am J Hypertens (2001) 14, 181A-182A; doi:S0895-7061(01)01620-X
- Publication
American Journal of Hypertension, 2001, Vol 14, p181A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01620-X