We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
P-620: Ambulatory blood pressure monitoring in children with cystic kidney diseases.
- Authors
Seeman, Tomas; Dusek, Jiri; Feber, Janusz; Vondrak, Karel; John, Ulrike; Misselwitz, Joachim; Janda, Jan
- Abstract
1. Arterial hypertension is a complication of cystic kidney diseases. In the present study we have evaluated the BP pattern in children with autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD) and unilateral multicystic kidney dysplasia (MCDK).2. Ambulatory blood pressure monitoring (ABPM) has been used as a potent tool for detection of arterial hypertension.141 children have been investigated: 95 children with ADPKD, 22 with ARPKD and 25 with MCDK. None of the children was treated by antihypertensive drugs. All children with ADPKD had normal glomerular filtration rate, 50% of children with ARPKD and 8% of children with MCDK were in chronic renal insufficiency. Four children with unilateral MCDK had reflux nephropathy or obstructive uropathy on the contralateral kidney. Hypertension was defined as systolic and/or diastolic daytime and/or nighttime ambulatory BP mean exceeding 95th percentile for healthy pediatric population (acc. Soergel et al.).3. Hypertension has been detected in 32% of children with ADPKD, 86% of children with ARPKD and 20% of children with MCDK. In children with ADPKD the ambulatory BP correlated significantly with the number of renal cysts and renal volume (r=0.29-0.44, p<0.05-0.01). Children with ARPKD had the most severe hypertension usually requiring double or triple antihypertensive drug therapy. In children with MCDK the hypertension was associated mainly with the damage of the contralateral - functional solitary - kidney.4. Cystic kidney diseases are often associated with arterial hypertension. Careful monitoring of BP in children with cystic kidney diseases is recommended. ABPM should be performed in all children with ARPKD, in children with ADPKD and increased renal volume or high number of renal cysts and in children with unilateral MCDK who show signs of contralateral kidney damage. Children with ARPKD usually require multiple antihypertensive drugs for sufficient BP control. Czech National Registry of children with cystic kidney diseases has been established since 1993 and nowadays 206 children with various types of cystic kidney diseases are registred.This project has been supported by grant IGA NE/6295-3.Am J Hypertens (2001) 14, 237A-238A; doi:S0895-7061(01)01927-6
- Publication
American Journal of Hypertension, 2001, Vol 14, p237A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01927-6