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- Title
Label-free DNA biosensing by topological light confinement.
- Authors
Zito, Gianluigi; Sanità, Gennaro; Guilcapi Alulema, Bryan; Lara Yépez, Sofía N.; Lanzio, Vittorino; Riminucci, Fabrizio; Cabrini, Stefano; Moccia, Maria; Avitabile, Concetta; Lamberti, Annalisa; Mocella, Vito; Rendina, Ivo; Romano, Silvia
- Abstract
Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge the gap of large effective mode volume with large experimental quality factor. Relying on the transduction mechanism of reactive sensing principle, herein, we first numerically study the potential of subwavelength confinement driven by topological decoupling from free space radiation for BIC-based biosensing. Then, we experimentally combine this capability with minimal and low-cost optical setup, applying the devised quasi-BIC resonator for PNA/DNA selective biosensing with real-time monitoring of the binding event. A sensitivity of 20 molecules per micron squared is achieved, i.e. ≃0.01 pg. Further enhancement can easily be envisaged, pointing out the possibility of single-molecule regime. This work aims at a precise and ultrasensitive approach for developing low-cost point-of-care tools suitable for routine disease prescreening analyses in laboratory, also adaptable to industrial production control.
- Subjects
DNA; ASTROPHYSICAL radiation; BOUND states; QUALITY factor; PRODUCTION control
- Publication
Nanophotonics (21928606), 2021, Vol 10, Issue 17, p4279
- ISSN
2192-8606
- Publication type
Article
- DOI
10.1515/nanoph-2021-0396