We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Functional sympatholysis is impaired in hypertensive humans.
- Authors
Vongpatanasin, Wanpen; Wang, Zhongyun; Arbique, Debbie; Arbique, Gary; Adams-Huet, Beverley; Mitchell, Jere H.; Victor, Ronald G.; Thomas, Gail D.
- Abstract
In healthy individuals, blunting of the vasoconstriction caused by activation of the sympathetic nervous system is thought to be an important mechanism that optimizes blood flow to the working muscles. We show for the first time that this protective mechanism, called functional sympatholysis, is impaired in middle-aged patients with high blood pressure. We also show that this impairment can be reversed by treatment with an angiotensin receptor blocker, but not with a thiazide-type diuretic. These findings indicate that angiotensin II may augment sympathetic vasoconstriction in the active muscles of hypertensive humans, which may explain the exaggerated rise in blood pressure and blunted decline in systemic vascular resistance during exercise in this population.
- Publication
Journal of Physiology, 2011, Vol 589, Issue 5, p1209
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2010.203026