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- Title
Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test® (Mekos test) sensitizing the tested patients?
- Authors
Stenberg, Berndt; Bruze, Magnus; Zimerson, Erik
- Abstract
Background. In a population study using TRUE Test®, we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizerswithin PTBP-FR in test preparations for TRUE Test® and Finn Chambers® were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explorewhether these groups reacted to different PTBP-FR sensitizers. Patients/materials/methods. Four individualswith late reactions and 5 subjectswith established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test® were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. Results. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjectswith suspected sensitizationhadsomewhat stronger reactions than controls. The concentrations ofmonomers, dimers and trimerswere generally higher in the TRUE Test® resin than in reference substances. Conclusions. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test® has a lower degree of polymerization or condensation,whichmay enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test® should be carried out.
- Subjects
ALLERGIES; ECZEMA; ALLERGENS; SKIN tests; CONTACT dermatitis; PHYSIOLOGICAL effects of formaldehyde
- Publication
Contact Dermatitis (01051873), 2015, Vol 73, Issue 6, p350
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.12401