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- Title
Metalworking exposures and persistent skin symptoms in the ECRHS II and SAPALDIA 2 cohorts.
- Authors
Mirabelli, Maria C.; Zock, Jan-Paul; Bircher, Andreas J.; Jarvis, Debbie; Keidel, Dirk; Kromhout, Hans; Norbäck, Dan; Olivieri, Mario; Plana, Estel; Radon, Katja; Schindler, Christian; Schmid-Grendelmeier, Peter; Torén, Kjell; Villani, Simona; Kogevinas, Manolis
- Abstract
Background: Diseases of the skin are important and often preventable conditions occurring among workers with dermal exposures to irritant and sensitizing agents. Objective: We conducted this analysis to assess the associations between metalworking exposures and current and persistent skin symptoms among male and female participants in two population-based epidemiologic studies. Methods: We pooled data from the European Community Respiratory Health Survey II (ECRHS II) and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults 2 (SAPALDIA 2), two prospective cohort studies in Europe. Each participant completed interviewer-administered questionnaires to provide information about symptoms and exposures related to selected occupations, including metalworking, during the follow-up periods. We assessed associations between skin symptoms and the frequency of metalworking exposures among 676 ECRHS II/SAPALDIA 2 respondents. Results: Current skin symptoms were reported by 10% of metalworkers and were associated with frequent use, defined as four or more days per week, of oil-based metalworking fluids [prevalence ratio (PR): 1.76, 95% confidence interval (CI): 1.25–2.49)] and organic solvent/degreasing agents (PR: 2.06, 95% CI: 1.21–3.50). Conclusions: Skin symptom prevalence is associated with increasing frequency of oil-based metalworking fluid and degreasing agent use. Our findings justify assessing strategies for reducing the frequency of metal-related exposures.
- Subjects
SKIN disease diagnosis; EPIDEMIOLOGICAL research; WORKPLACE exposure to hazardous substances; OCCUPATIONAL dermatitis; DERMATOTOXICOLOGY; INDUSTRIAL contamination; DIAGNOSIS
- Publication
Contact Dermatitis (01051873), 2009, Vol 60, Issue 5, p256
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.2009.01525.x