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- Title
Comparative Analysis of immune Activation Markers of CD8<sup>+</sup> T Cells in lymph Nodes of Different Origins in siV-infected chinese rhesus Macaques.
- Authors
Jinbiao Liu; Qianhao Xiao; Runhong Zhou; Yong Wang; Qiaoyang Xian; Tongcui Ma; Ke Zhuang; Li Zhou; Deyin Guo; Xu Wang; Wen-Zhe Ho; Jieliang Li; Caputo, Antonella; Catalfamo, Marta
- Abstract
Altered T-cell homeostasis, such as expansion of CD8+ T cells to the secondary lymphatic compartments, has been suggested as a mechanism of HIV/simian immunodeficiency virus (SlV)-pathogenesis. However, the role of immune activation of CD8+ T cells in the CD4/CD8 turnover and viral replication in these tissues is not completely understood. In this study, we compared the expression of immune activation markers (CD69 and HLA-DR) on CD8+ T cells in the peripheral blood and lymph nodes (LNs) of SlV-infected/ uninfected Chinese rhesus macaques. SlV-infected macaques had significantly higher percentages of CD8+CD69+ and CD8+HLA-DR+ T cells in all these anatomical compartments than uninfected macaques. LNs that located close to the gastrointestinal (Gl) tract (colon, mesenteric, and iliac LNs) of SlV-infected macaques had profoundly lower numbers of CD4+ T cells, but no significant difference in expression of activation marker (CD8+CD69+ and CD8+HLA-DR+) as compared with the peripheral lymphatic tissues (axillary and inguinal LNs). The CD4/CD8 ratios were negatively correlated with the activation of CD8+ T cells in the overall LNs, with further associations with CD8+HLA-DR+ in Gl LNs while CD8+CD69+ in peripheral LNs. These observations demonstrate that the increase of CD8+ T cell activation is a contributing factor for the decline of CD4/CD8 ratios in Gl system.
- Subjects
LYMPH node physiology; T cells; SIMIAN immunodeficiency virus diseases; IMMUNOLOGY
- Publication
Frontiers in Immunology, 2016, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00371