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- Title
Correlations of HHV-6 viral load and plasma IL-6 concentration with HHV-6 encephalitis in allogeneic stem cell transplant recipients.
- Authors
Ogata, M.; Satou, T.; Kawano, R.; Takakura, S.; Goto, K.; Ikewaki, J.; Kohno, K.; Ikebe, T.; Ando, T.; Miyazaki, Y.; Ohtsuka, E.; Saburi, Y.; Saikawa, T.; Kadota, J.
- Abstract
This study investigated factors associated with the development of human herpesvirus (HHV)-6 encephalitis. Among 111 enrolled subjects, 12 patients developed central nervous system (CNS) dysfunction. CNS dysfunction in four patients was found to have no association with HHV-6. The remaining eight patients displayed HHV-6 encephalitis (n=3), limbic encephalitis (HHV-6 DNA in cerebrospinal fluid was not examined; n=3) or CNS dysfunction because of an unidentified cause (n=2). Real-time PCR showed CNS dysfunction in the latter eight patients, which developed concomitant with the appearance of high plasma levels of HHV-6 DNA (104 copies/ml). Overall, eight of the 24 patients with high-level HHV-6 DNA developed CNS dysfunction, whereas no patients developed CNS dysfunction potentially associated with HHV-6 infection if peak HHV-6 DNA was <104 copies/ml. We next analyzed plasma concentrations of IL-6, IL-10 and tumor necrosis factor-α among patients who displayed high-level plasma HHV-6 DNA and found elevated IL-6 concentrations preceding HHV-6 infection in patients who developed CNS dysfunction. (Mean±s.d.: 865.7±1036.3 pg/ml in patients with CNS dysfunction; 56.5±192.9 pg/ml in others; P=0.01). These results suggest that high-level HHV-6 load is necessary for the development of HHV-6 encephalitis, and systemic inflammatory conditions before HHV-6 infection form the preparatory conditions for progression to encephalopathy.
- Subjects
STEM cell transplantation; HUMAN herpesvirus-6; CENTRAL nervous system diseases; ENCEPHALITIS; CEREBROSPINAL fluid
- Publication
Bone Marrow Transplantation, 2010, Vol 45, Issue 1, p129
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2009.116