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- Title
Circulating GLP-1 in infants born small-for-gestational-age: breast-feeding versus formula-feeding.
- Authors
Díaz, M; Bassols, J; Sebastiani, G; López-Bermejo, A; Ibáñez, L; de Zegher, F; Díaz, M; López-Bermejo, A; Ibáñez, L
- Abstract
Prenatal growth restraint associates with the risk for later diabetes, particularly if such restraint is followed by postnatal formula-feeding (FOF) rather than breast-feeding (BRF). Circulating incretins can influence the neonatal programming of hypothalamic setpoints for appetite and energy expenditure, and are thus candidate mediators of the long-term effects exerted by early nutrition. We have tested this concept by measuring (at birth and at age 4 months) the circulating concentrations of glucagon-like peptide-1 (GLP-1) in BRF infants born appropriate-for-gestational-age (AGA; n=63) and in small-for-gestational-age (SGA) infants receiving either BRF (n=28) or FOF (n=26). At birth, concentrations of GLP-1 were similar in AGA and SGA infants. At 4 months, pre-feeding GLP-1 concentrations were higher than at birth; SGA-BRF infants had GLP-1 concentrations similar to those in AGA-BRF infants but SGA-FOF infants had higher concentrations. In conclusion, nutrition appears to influence the circulating GLP-1 concentrations in SGA infants and may thereby modulate long-term diabetes risk.
- Subjects
HYPOTHALAMUS physiology; BIRTH size; BREASTFEEDING; COMPARATIVE studies; INFANT formulas; INFANTS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; NEUROPLASTICITY; NUTRITIONAL requirements; RESEARCH; GLUCAGON-like peptide 1; EVALUATION research; ADIPONECTIN
- Publication
International Journal of Obesity, 2015, Vol 39, Issue 10, p1501
- ISSN
0307-0565
- Publication type
journal article
- DOI
10.1038/ijo.2015.117