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- Title
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus.
- Authors
Park, Pojeong; Georgiou, John; Sanderson, Thomas M.; Ko, Kwang-Hee; Kang, Heather; Kim, Ji-il; Bradley, Clarrisa A.; Bortolotto, Zuner A.; Zhuo, Min; Kaang, Bong-Kiun; Collingridge, Graham L.
- Abstract
Long-term potentiation (LTP) at hippocampal CA1 synapses can be expressed by an increase either in the number (N) of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors or in their single channel conductance (γ). Here, we have established how these distinct synaptic processes contribute to the expression of LTP in hippocampal slices obtained from young adult rodents. LTP induced by compressed theta burst stimulation (TBS), with a 10 s inter-episode interval, involves purely an increase in N (LTPN). In contrast, either a spaced TBS, with a 10 min inter-episode interval, or a single TBS, delivered when PKA is activated, results in LTP that is associated with a transient increase in γ (LTPγ), caused by the insertion of calcium-permeable (CP)-AMPA receptors. Activation of CaMKII is necessary and sufficient for LTPN whilst PKA is additionally required for LTPγ. Thus, two mechanistically distinct forms of LTP co-exist at these synapses. Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance, via insertion of calcium-permeable AMPA receptors.
- Subjects
AMPA receptors; LONG-term potentiation; HIPPOCAMPUS (Brain); PROPIONIC acid; YOUNG adults; TRP channels
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-20523-3