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- Title
Longitudinal evaluation of fecal microbiota transplantation for ameliorating calf diarrhea and improving growth performance.
- Authors
Kim, Hyun Sik; Whon, Tae Woong; Sung, Hojun; Jeong, Yun-Seok; Jung, Eun Sung; Shin, Na-Ri; Hyun, Dong-Wook; Kim, Pil Soo; Lee, June-Young; Lee, Choong Hwan; Bae, Jin-Woo
- Abstract
Calf diarrhea is associated with enteric infections, and also provokes the overuse of antibiotics. Therefore, proper treatment of diarrhea represents a therapeutic challenge in livestock production and public health concerns. Here, we describe the ability of a fecal microbiota transplantation (FMT), to ameliorate diarrhea and restore gut microbial composition in 57 growing calves. We conduct multi-omics analysis of 450 longitudinally collected fecal samples and find that FMT-induced alterations in the gut microbiota (an increase in the family Porphyromonadaceae) and metabolomic profile (a reduction in fecal amino acid concentration) strongly correlate with the remission of diarrhea. During the continuous follow-up study over 24 months, we find that FMT improves the growth performance of the cattle. This first FMT trial in ruminants suggest that FMT is capable of ameliorating diarrhea in pre-weaning calves with alterations in their gut microbiota, and that FMT may have a potential role in the improvement of growth performance. Here, the authors report the results of a longitudinal multi-omics trial of the use of fecal microbiota transplantation (FMT) to ameliorate diarrhea and restore gut microbial composition in 57 growing calves, and find that oral FMT induces alterations in the gut microbiota correlate with the remission of diarrhea and improves the growth performance of the cattle.
- Subjects
FECAL microbiota transplantation; CALVES; DIARRHEA; CATTLE growth; ANTIBIOTIC overuse; INTESTINAL infections; BOVINE viral diarrhea
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-20389-5