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- Title
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque .
- Authors
Xueqi Wan; Jinfan Tian; Peng Hao; Kuo Zhou; Jing Zhang; Yuquan Zhou; Changjiang Ge; Xiantao Song
- Abstract
The important role of Ca2+ in pathogenic store-operated calcium entry (SOCE) is well-established. Among the proteins involved in the calcium signaling pathway, Stromal interacting molecule 1 (STIM1) is a critical endoplasmic reticulum transmembrane protein. STIM1 is activated by the depletion of calcium stores and then binds to another calcium protein, Orai1, to form a channel through which the extracellular Ca2+ can enter the cytoplasm to replenish the calcium store. Multiple studies have shown that increased STIM1 facilitates the aberrant proliferation and apoptosis of vascular smooth cells (VSMC) and macrophages which can promote the formation of rupture-prone plaque. Together with regulating the cytosolic Ca2+ concentration, STIM1 also activates STING through altered intracellular Ca2+ concentration, a critical pro-inflammatory molecule. The cGAS-STING pathway is linked with cellular proliferation and phenotypic conversion of VSMC and enhances the progression of atherosclerosis plaque. In summary, we conclude that STIM1/cGAS-STING is involved in the progression of AS and plaque vulnerability.
- Subjects
ATHEROSCLEROTIC plaque; MEMBRANE proteins; EXTRACELLULAR fluid
- Publication
Aging & Disease, 2022, Vol 13, Issue 6, p1606
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2022.0417