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- Title
Polymorphism –509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population.
- Authors
Zhu, Xin-Jie; Lu, Mei-Ping; Chen, Ruo-Xi; Bu, Dong-Yun; Zhu, Lu-Ping; Wang, Mei-Lin; Yin, Min; Zhang, Zheng-Dong; Cheng, Lei
- Abstract
Background: Polymorphism –509C/T in the promoter of transforming growth factor beta1 (TGFB1) gene is implicated in the pathogenesis of asthma. This polymorphism might also act to regulate the development of allergic rhinitis (AR). Objectives: To investigate whether –509C/T is associated with AR susceptibility and severity in a Han Chinese population. Methods: The study enrolled 263 patients with persistent AR and 249 healthy controls. AR patients were classified as mild or moderate/severe AR groups according to the Allergic Rhinitis and its Impact on Asthma classification. TGFB1 gene polymorphism –509C/T was genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum total Immunoglobulin E (IgE) and specific IgE levels were determined using an ImmunoCAP. Results: Significant difference was found in the allele frequency of TGFB1 –509C/T between AR patients and healthy controls (P =.027) but not in the genotype frequency (P =.051). However, the genotype frequency of TGFB1 –509C/T showed significant difference between the mild AR group, the moderate/severe AR group, and the control group (P =.012); between the moderate/severe AR group and the control group (P =.036); between the mild AR group and the moderate/severe AR group (P =.038); but not between the mild AR group and the control group (P =.075). Conclusion: TGFB1 promoter polymorphism –509C/T may be associated with the susceptibility and the severity of persistent AR of Han Chinese, but the functional relationship still needs clarification.
- Subjects
CHINESE people; ALLERGIC rhinitis; TRANSFORMING growth factors; IMMUNOGLOBULIN E; PATHOLOGY; GENETIC polymorphisms
- Publication
American Journal of Rhinology & Allergy, 2020, Vol 34, Issue 5, p597
- ISSN
1945-8924
- Publication type
Article
- DOI
10.1177/1945892420913441