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- Title
Immunogenicity and evolutionary variability of epitopes within lgA1 protease from serogroup A Neisseria meningitidis.
- Authors
Morelli, Giovanna; Del Valle, Jesús; Lammel, Claudia J.; Pohlner, Johannes; Müller, Kerstin; Blake, Milan; Brooks, Geo F.; Meyer, Thomas F.; Koumaré, Brehima; Brieske, Norbert; Achtman, Mark
- Abstract
Five murine epitopes were defined and mapped within IgA1 protease produced by <em>Neisseria meningitidis</em>. Epitopes 1 and 2 were present in IgA1 protease from all strains, and from Neisseria gonorrhoeae. Epitopes 3 through to 5 varied between subgroups of serogroup A meningococci, but have remained constant over decades within the subgroups, except for epitope 4, which changed between 1983 and 1987 during the spread of subgroup III meningococci from Asia to Africa. Binding of monoclonal antibodies to epitopes 1, 4 and 5 neutralized enzymatic function. Human sera containing antibodies to IgA1 protease as a result of natural infection inhibited binding of monoclonal anti-bodies to epitope 4 but not to the other epitopes.
- Subjects
NEISSERIA meningitidis; IMMUNOGENETICS; EPITOPES; PROTEOLYTIC enzymes; MONOCLONAL antibodies
- Publication
Molecular Microbiology, 1994, Vol 11, Issue 1, p175
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/j.1365-2958.1994.tb00299.x