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- Title
Regeneration of the basal lamina complex during epithelial wound healing.
- Authors
Sciubba, James J.
- Abstract
The purpose of this study was to follow the time sequence of events in the reformation of the attachment complex between epithelium and lamina propria of oral mucosa following incisional wounding. An incisional wound of minimal depth was made along the dorsal surface of rat tongue. From nine groups of animals, tissue specimens were collected from 0 through 96 hours and processed routinely for electron microscopy. The formation of the attachment complex was followed in relation to the epithelial cells migrating across the wound space. The earliest discernable changes denoting initiation of reattachment were preceded by a short period of direct contact between epithelial plasma membrane and fibrin. Attachment did not occur in epithelial cells not bordering on fibrin, suggesting that in the system studied such contact is a prerequisite for reattachment. The ultrastructural components of the attachment complex appeared in an orderly chronologic and spatial sequence, with the additional components appearing as time elapsed between the arrival of the cell in its new location and the collection of the tissue specimen.
- Subjects
HEALING; EPITHELIUM; WOUND healing; MUCOUS membranes; EPITHELIAL cells; ELECTRON microscopy
- Publication
Journal of Periodontal Research, 1977, Vol 12, Issue 3, p204
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.1977.tb00123.x