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- Title
Small Protein-Mediated Quorum Sensing in a Gram- Negative Bacterium.
- Authors
Sang-Wook Han; Sriariyanun, Malinee; Sang-Won Lee; Sharma, Manoj; Bahar, Ofir; Bower, Zachary; Ronald, Pamela C.
- Abstract
The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axYS22, derived from the Ax21 (activator of XA21-mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.
- Subjects
XANTHOMONAS; PSEUDOMONADACEAE; BIOLOGICAL transport; QUORUM sensing; CELL communication; MICROBIAL genetics
- Publication
PLoS ONE, 2011, Vol 6, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0029192