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- Title
Vitamin D receptor: A highly versatile nuclear receptor.
- Authors
Wu-Wong, J. R.
- Abstract
Vitamin D receptor (VDR) modulators are used to treat hyperparathyroidism secondary to chronic kidney disease (CKD). The therapy is associated with reduced mortality in stage 5 CKD patients, who experience an extremely high cardiovascular disease (CVD)-related mortality rate. Chen et al. report that VDR is involved in regulating type A natriuretic peptide receptor (NPR-A) in inner medullary collecting duct cells. The regulation of NPR-A may be one of several mechanisms by which VDR activation reduces CVD risk in CKD.Kidney International (2007) 72, 237–239. doi:10.1038/sj.ki.5002428
- Subjects
VITAMIN D; HYPERPARATHYROIDISM treatment; KIDNEY diseases; ATRIAL natriuretic peptides; CARDIOVASCULAR diseases; PEPTIDE hormones
- Publication
Kidney International, 2007, Vol 72, Issue 3, p237
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002428