We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome
- Authors
Khajehei, Marjan; Abdali, Khadijeh; Parsanezhad, Mohammad Ebrahim; Tabatabaee, Hamid Reza
- Abstract
<bold>Objective: </bold>To compare the effects of dydrogesterone and calcium plus vitamin D in women with severe premenstrual syndrome (PMS).<bold>Method: </bold>In this randomized, double-blind, placebo-controlled study, 180 Shiraz University students with PMS used questionnaires daily to rate their symptoms for 2 menstrual cycles. Then, the students were randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of the cycle for 2 more cycles, and to use the same questionnaires during the intervention cycles. The collected data were then analyzed by repeated-measurement design and multilevel modeling tests.<bold>Result: </bold>Treatment with dydrogesterone or calcium plus vitamin D decreased symptom severity in a similar way (by 4.64% and 4.20%, respectively) and placebo was associated with a 3.42% decrease.<bold>Conclusion: </bold>Treatment with dydrogesterone or calcium plus vitamin D had a similar effect on symptom severity in women with PMS.
- Subjects
PROGESTATIONAL hormones; HORMONE therapy; THERAPEUTIC use of vitamin D; PREMENSTRUAL syndrome treatment; DANISHGAH-i Shiraz; STUDENT health; REPEATED measures design; DRUG efficacy; CALCIUM; THERAPEUTIC use of progestational hormones; STEROID drugs; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PREMENSTRUAL syndrome; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; THERAPEUTICS
- Publication
International Journal of Gynecology & Obstetrics, 2009, Vol 105, Issue 2, p158
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2009.01.016