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- Title
Pax5 – a Critical Inhibitor of Plasma Cell Fate.
- Authors
Nera, K.-P.; Lassila, O.
- Abstract
Paired box protein 5 (Pax5) is essential for early B cell commitment as well as for B cell development, and continuous expression of Pax5 is required throughout the B cell lineage to maintain the functional identity of B cells. During B cell activation, Pax5 is downregulated before terminal differentiation into antibody-secreting plasma cells, and enforced expression of Pax5 prevents plasmacytic development. Recently, loss of Pax5 was shown to result in the substantial transition to a plasma cell state, demonstrating a functionally significant role for Pax5 in the regulation of terminal B cell differentiation. Here we elucidate the current understanding about the function of Pax5 as a key inhibitor of plasma cell differentiation.
- Subjects
B cells; LYMPHOID tissue; CELL differentiation; MORPHOGENESIS; PLASMA cells; LYMPHOCYTES
- Publication
Scandinavian Journal of Immunology, 2006, Vol 64, Issue 3, p190
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2006.01809.x