We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Enhanced Control of an Outbreak of Mycoplasma pneumoniae Pneumonia with Azithromycin Prophylaxis.
- Authors
Klausner, Jeffrey D.; Passaro, Douglas; Rosenberg, Jon; Thacker, W. Lanier; Talkington, Deborah F.; Werner, S. Benson; Vugia, Duc J.
- Abstract
There are currently no recommended epidemic-control measures for Mycoplasma pneumoniae pneumonia outbreaks in closed communities. Previous studies have suggested the usefulness of chemoprophylaxis administered to close contacts of case-patients. To evaluate the effectiveness of various epidemiccontrol measures during an institutional outbreak, an observational study was undertaken during a very large outbreak of M. pneumoniae pneumonia at a facility for developmentally disabled residents (n = 142 cases). Control measures evaluated included no control, standard epidemic-control measures, and targeted azithromycin prophylaxis (500 mg on day 1, 250 mg/day on days 2–5) plus standard epidemiccontrol measures. The combined use of azithromycin prophylaxis and standard epidemic-control measures was associated with a significant reduction in the secondary attack rate. This study suggests that the addition of antibiotic prophylaxis to standard epidemic-control measures can be useful during institutional outbreaks of M. pneumoniae pneumonia.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 1, p161
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/513818