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- Title
Neutralization of a Clade B Primary Isolate by Sera from Human Immunodeficiency Virus-Uninfected Recipients of Candidate AIDS Vaccines.
- Authors
Zolla-Pazner, Susan; Alving, Carl; Belshe, Robert; Berman, Phillip; Burda, Sherri; Chigurupati, Padmasree; Clements, Mary Lou; Duliege, Anne-Marie; Excler, Jean-Louis; Hioe, Catarina; Kahn, James; McElrath, M. Juliana; Sharpe, Sandra; Sinangil, Faruk; Steimer, Kathelyn; Walker, Mary Clare; Wassef, Nabila; Xu, Serena
- Abstract
The inability of antibodies induced by experimental human immunodeficiency virus type 1 (HIV- 1) vaccines to neutralize HIV-1 primary isolates may be due to a failure to elicit such antibodies, antigenic differences between the vaccine and the strains tested, insensitivity of the assays used, or to a combination of factors. New neutralization assays were used to determine the ability of candidate AIDS vaccines to generate neutralizing antibodies for clade B primary isolate BZ167, which is closely related in portions of its envelope to the immunizing strains. Sera from HIV-uninfected volunteers in vaccine trials were tested, and neutralizing activity was found in recipients of recombinant (r) gp120MN or of rgp160MN-containing canarypox boosted with rgp120SF-2. Detection of antibodies that neutralize primary isolate BZ167 correlated with neutralizing activity for homologous vaccine strains. These data demonstrate that certain candidate AIDS vaccines can elicit antibodies that neutralize a primary isolate of HIV-1.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 4, p764
- ISSN
0022-1899
- Publication type
Article