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- Title
Late Acquisition of Hyporesponsiveness to Lipopolysaccharide by Mycobacterium avium-Infected Human Macrophages in Producing Tumor Necrosis Factor-α but Not Interleukin-lβ and -6.
- Authors
Fattorini, Lanfranco; Xiao, Yan; Ausiello, Clara M.; Urbani, Francesca; laSala, Andrea; Mattei, Maurizio; Orefici, Graziella
- Abstract
To investigate whether infection with Mycobacterium avium modifies the cytokine response of human macrophages (Mφ) to lipopolysaccharide (LPS), the release of interleukin (IL)-lβ, IL-6, and tumor necrosis factor (TNF)-α was determined in infected and uninfected Mφ, unstimulated or stimulated with LPS. In unstimulated Mφ, the release of IL-lβ and IL-6 increased with the progress of infection while that of TNF-α progressively decreased. When Mφ were stimulated with LPS, IL-lβ and IL-6 levels were always higher in infected than in uninfected cells, but levels of TNF-α significantly decreased in infected Mφ. A similar trend was obtained for TNF-α mRNA expression. Altogether, these results indicate that infected Mφ react to LPS stimulus with enhanced levels of IL-1β and IL-6 but are unable to restore the production of TNF-α impaired by the growth of the intracellular mycobacteria.
- Publication
Journal of Infectious Diseases, 1996, Vol 173, Issue 4, p1030
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/173.4.1030