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- Title
Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity.
- Authors
Briss, Peter A.; Fehrs, Laura J.; Parker, Robert A.; Wright, Peter F.; Sannella, Edith C.; Hutcheson, R. H.; Schaffner, William; Briss, P A; Fehrs, L J; Parker, R A; Wright, P F; Sannella, E C; Schaffner, W
- Abstract
From January to July 1991, an outbreak of mumps occurred in Maury County, Tennessee. At the primarily affected high school, where 98% of students and all but 1 student with mumps had been vaccinated before the outbreak, 68 mumps cases occurred among 1116 students (attack rate, 6.1%). Students vaccinated before 1988 (the first year mumps vaccination was required for school attendance in Tennessee) may have been at greater risk of mumps than those vaccinated later (65 [6.1%] of 1001 vs. 2 [2.2%] of89; risk ratio, 2.9; 95% confidence interval, 0.7–11.6). Of 13 persons with confirmed mumps who underwent serologic testing, 3 lacked IgM antibody in well-timed acute- and convalescent-phase serum specimens. Vaccine failure accounted for a sustained mumps outbreak in a highly vaccinated population. Most mumps cases were attributable to primary vaccine failure. It is possible that waning vaccine-induced immunity also played a role.
- Publication
Journal of Infectious Diseases, 1994, Vol 169, Issue 1, p77
- ISSN
0022-1899
- Publication type
journal article