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- Title
Chlamydia pneumoniaein the cerebrospinal fluid of patients with multiple sclerosis and neurological controls.
- Authors
Sotgiu, S; Piana, A; Pugliatti, M; Sotgiu, A; Deiana, GA; Sgaramella, E; Muresu, E; Rosati, G
- Abstract
Chlamydia pneumoniaeinfection is a common event in neurological patients and recovery of C. pneumoniaeDNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniaeinfection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniaeantibodies. However, C. pneumoniaeDNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniaepersistence in some MS patients may be the result of an impaired clearance within the central nervous system.
- Subjects
CHLAMYDOPHILA pneumoniae infections; MULTIPLE sclerosis; CEREBROSPINAL fluid; POLYMERASE chain reaction
- Publication
Multiple Sclerosis (13524585), 2001, Vol 7, Issue 6, p371
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1191/135245801701567087