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- Title
Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML‐05 study.
- Authors
Aoki, Takahiro; Takahashi, Hiroyuki; Tanaka, Shiro; Shiba, Norio; Hasegawa, Daiichiro; Iwamoto, Shotaro; Terui, Kiminori; Moritake, Hiroshi; Nakayama, Hideki; Shimada, Akira; Koh, Katsuyoshi; Goto, Hiroaki; Kosaka, Yoshiyuki; Saito, Akiko M.; Horibe, Keizo; Kinoshita, Akitoshi; Tawa, Akio; Taga, Takashi; Adachi, Souichi; Tomizawa, Daisuke
- Abstract
Summary: The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML‐05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte‐colony stimulating factor (G‐CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.
- Subjects
ACUTE myeloid leukemia; PROGNOSIS; GRANULOCYTE-colony stimulating factor; LEUKEMIA; NEUTROPENIA
- Publication
British Journal of Haematology, 2021, Vol 193, Issue 1, p176
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.16656