We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors.
- Authors
Malcikova, Jitka; Stalika, Evangelia; Davis, Zadie; Plevova, Karla; Trbusek, Martin; Mansouri, Larry; Scarfò, Lydia; Baliakas, Panagiotis; Gardiner, Anne; Sutton, Lesley ‐ Ann; Francova, Hana Skuhrova; Agathangelidis, Andreas; Anagnostopoulos, Achilles; Tracy, Ian; Makris, Antonis; Smardova, Jana; Ghia, Paolo; Belessi, Chrysoula; Gonzalez, David; Rosenquist, Richard
- Abstract
The article discusses the research on the frequency of TP53 gene defects between chronic lymphocytic leukemia subgroups harbouring distinct antigen receptors. It states that chronic lymphocytic leukemia (CLL) B-cell receptor (BcR) stereotypes exhibit distinct profiles of genomic aberrations. It mentions that the BcR-mediated selection as possible mechanism for acquisition or selection of genomic aberrations in CLL.
- Subjects
P53 protein; CHRONIC lymphocytic leukemia; ANTIGEN receptors; B cells; CHROMOSOME abnormalities
- Publication
British Journal of Haematology, 2014, Vol 166, Issue 4, p621
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12893