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- Title
Plasma endothelinlike immunoreactivity levels in IDDM patients with microalbuminuria.
- Authors
Collier, Andrew; Leach, John P.; McLellan, Alistair; Jardine, Alan; Morton, James J.; Small, Michael; Collier, A; Leach, J P; McLellan, A; Jardine, A; Morton, J J; Small, M
- Abstract
<bold>Objective: </bold>To determine whether plasma endothelin, a potent vasoconstrictor and growth factor for vascular smooth muscle, is elevated in microalbuminuric insulin-dependent diabetes mellitus patients.<bold>Research Design and Methods: </bold>Plasma endothelinlike immunoreactivity was measured by radioimmunoassay in 15 microalbuminuric diabetic patients, 12 normoalbuminuric diabetic patients, and 12 control subjects.<bold>Results: </bold>The mean levels of plasma endothelinlike immunoreactivity were raised in the normoalbuminuric patients (8.4 pM [range 4.8-12.7 pM]; P less than 0.01) and the microalbuminuric patients (10.2 pM [range 5.6-31.1 pM]; P less than 0.001) compared with control subjects (6.1 pM [range 4.5-7.6 pM]). Plasma endothelinlike immunoreactivity was also higher in the microalbuminuric patients compared with the normoalbuminuric patients (P less than 0.05).<bold>Conclusions: </bold>The increase in plasma endothelinlike immunoreactivity further confirms endothelial dysfunction in diabetes and this increase in plasma endothelin may contribute to the vascular disease prevalent in diabetes.
- Publication
Diabetes Care, 1992, Vol 15, Issue 8, p1038
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.15.8.1038