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- Title
Net reclassification index in comparison of prognostic value of disseminated intravascular coagulation diagnostic criteria by Japanese Society on Thrombosis and Hemostasis and International Society on Thrombosis and Haemostasis: a multicenter prospective cohort study
- Authors
Mori, Hirotaka; Harada-Shirado, Kayo; Kawano, Noriaki; Hayakawa, Mineji; Seki, Yoshinobu; Uchiyama, Toshimasa; Yamakawa, Kazuma; Ishikura, Hiroyasu; Irie, Yuhei; Nishio, Kenji; Yada, Noritaka; Okamoto, Kohji; Ikezoe, Takayuki
- Abstract
Background: We compared the prognostic value of the Japanese Society on Thrombosis and Hemostasis (JSTH) disseminated intravascular coagulation (DIC) diagnostic criteria with that of the International Society on Thrombosis and Haemostasis (ISTH) DIC diagnostic criteria for 28-day in-hospital mortality. Methods: We conducted a multicenter prospective cohort study involving two hematology departments, four emergency departments, and one general medicine department in Japan between August 2017 and July 2021. We assessed three ISTH DIC diagnostic criteria categories using low cutoff levels of D-dimer (low D-dimer), high cutoff levels of D-dimer (high D-dimer), and fibrinogen/fibrin degradation products (FDP) as fibrin-related markers. The main outcome was diagnosis-based category additive net reclassification index (NRI). Results: A total of 222 patients were included: 82 with hematopoietic disorders, 86 with infections, and 54 with other diseases. The 28-day in-hospital mortality rate was 14% (n = 31). The DIC rates diagnosed by the JSTH, ISTH-low D-dimer, high D-dimer, and FDP DIC diagnosis were 52.7%, 47.3%, 42.8%, and 27.0%, respectively. The overall category additive NRI by JSTH DIC diagnosis vs. ISTH-low D-dimer, high D-dimer, and FDP DIC diagnosis were − 10 (95% confidence interval [CI]: −28 to 8, p = 0.282), − 7.8 (95% CI: −26 to 10, p = 0.401), and − 11 (95% CI: −26 to 3, p = 0.131), respectively. Conclusions: JSTH criterion showed the highest sensitivity for DIC diagnosis that did not improve but reflected the same prognostic value for mortality evaluated using ISTH DIC diagnosis criteria. This finding may help clinicians to use JSTH DIC criterion as an early intervention strategy in patients with coagulopathy.
- Subjects
DISSEMINATED intravascular coagulation; THROMBOSIS; RESEARCH; CONFIDENCE intervals; CLASSIFICATION; HEMOSTASIS; HOSPITAL mortality; RESEARCH funding; MEDICAL societies; LONGITUDINAL method; FIBRIN fibrinogen degradation products; EARLY medical intervention
- Publication
Thrombosis Journal, 2023, Vol 21, Issue 1, p1
- ISSN
1477-9560
- Publication type
Article
- DOI
10.1186/s12959-023-00523-1