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- Title
Spontaneous adenolipoma of the mammary gland in the male F344 rat.
- Authors
Tetsuya Ide; Young-Man Cho; Yuji Oishi; Kumiko Ogawa
- Abstract
A 110-week-old male F344 rat from the high-dose group of a 104-week carcinogenicity study, exhibited a spontaneously occurring subcutaneous mass in the left axilla extending to the chest. Histologically, the mass was well-demarcated from the adjacent mammary tissue and slightly encapsulated without evidence of infiltration into the surrounding tissues. The mass contained both epithelial and adipose components. The epithelial component consisted of ductal structures of various sizes lined by a single layer of flattened to cuboidal epithelial cells with relatively clear or vacuolated cytoplasm. These ductal structures were well-intermingled with an adipose component that consisted of a uniform monomorphic cell population of mature adipocytes. Both cell types were welldifferentiated and did not exhibit cellular atypia. Within the mass, fibrous connective tissue was found in the stroma with infiltration of numerous mast cells. Based on these findings, the mass was diagnosed as an adenolipoma of the mammary gland.
- Subjects
CONNECTIVE tissues; RATS; CELL populations; MAST cells; EPITHELIAL cells; MAMMARY glands; FAT cells
- Publication
Journal of Toxicologic Pathology, 2021, Vol 34, Issue 3, p231
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2021-0012