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- Title
Age-related biochemical changes in human Descemet's membrane.
- Authors
Freeman, Ian L.; Vergnes, Jean-Paul; Brown, Stuart I.; Freeman, I L; Vergnes, J P; Brown, S I
- Abstract
The effect of age on the compositional analysis of human Descemet's membrane was examined. Membranes were obtained from human corneas ranging from 0.5 to 95 years and purified by sodium dodecyl sulfate (SDS) extraction. Substantial age-related changes were obtained in the amino acid compositions of the SDS-insoluble basement membranes. These results suggested that compositonal changes occur during the aging process, which appeared to reflect an alteration in the subunit make-up of the basement membrane.
- Subjects
AMINO acid analysis; AGING; COLLAGEN; COMPARATIVE studies; CORNEA; RESEARCH methodology; MEDICAL cooperation; BASAL lamina; RESEARCH; EVALUATION research
- Publication
Gerontology, 1980, Vol 26, Issue 4, p217
- ISSN
0304-324X
- Publication type
journal article
- DOI
10.1159/000212417