We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Maternal and neonatal outcome of labour induction at term comparing two regimens of misoprostol.
- Authors
Kreft, Martina; Krähenmann, Franziska; Roos, Malgorzata; Kurmanavicius, Juozas; Zimmermann, Roland; Ochsenbein-Kölble, Nicole
- Abstract
Aim: To compare the efficacy and safety of two misoprostol dosing regimens for induction of labour in primiparous (1P) and multiparous (>1P) women. Methods: Retrospective study of induction of labour using vaginal misoprostol 25 μg vs. 50 μg every 6 h in 942 women at a tertiary centre. The main outcome variables are induction-to-delivery interval, latency period duration, vaginal delivery within 24 h, and maternal and foetal safety outcome. Results: With the 50 μg regimen, induction-to-delivery intervals were significantly shorter: 18.4 h vs. 24.6 h (1P) and 14 h vs. 17.9 h (>1P), as was latency period duration (by 5.4 and 4 h, respectively). Vaginal delivery within 24 h was significantly more frequent, as were non-reassuring foetal heart rate (1P: 20% vs. 14%) and tachysystole (1P: 31% vs. 11%; >1P: 21% vs. 7%). No uterine rupture was reported. Neonatal outcomes were similar except for significantly more frequent infant referral to neonatal intensive care in the >1P group receiving the 50 μg regimen (11% vs. 4%). Conclusion: Vaginal misoprostol 25 μg seems to maintain efficacy with more acceptable maternal and neonatal safety. As induction of labour is an off-label use for misoprostol, safety should be prioritised with the lower dosage regimen despite the longer induction-to-delivery interval.
- Subjects
SWITZERLAND; ACADEMIC medical centers; COST effectiveness; DOSE-response relationship in biochemistry; FISHER exact test; INDUCED labor (Obstetrics); MEDICAL records; HEALTH outcome assessment; SAFETY; WORLD Health Organization; TREATMENT effectiveness; OFF-label use (Drugs); RETROSPECTIVE studies; MISOPROSTOL; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; PHARMACODYNAMICS; PREGNANCY
- Publication
Journal of Perinatal Medicine, 2014, Vol 42, Issue 5, p603
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2013-0215