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- Title
Optimal Time for Initiation of Helicobacter pylori Eradication in Patients with Peptic Ulcer.
- Authors
Young Sin Cho; Sun Moon Kim; Kyung Ho Song; Sun Hyung Kang; Hee Seok Moon; Jae Kyu Sung; Seung Woo Lee; Ki Bae Bang; Ki Bae Kim; Il-kwun Chung; Dong Soo Lee; Hyun Yong Jeong; Sei Jin Youn
- Abstract
Background/Aims Helicobacter pylori eradication and additional treatment of ulcer healing are necessary for H. pylori-positive patients with an active peptic ulcer. However, there is no uniform guideline for whether H. pylori eradication should be initially or later in the treatment process. Therefore, this study was conducted to evaluate whether differences in the timing of eradication therapy in peptic ulcer impacts success rates in eradicating H. pylori. Methods Subjects were randomly assigned early eradication group (eradication treatment within 2 weeks) or late eradication group (eradication treatment after 8 weeks). Successful eradication was defined as negative 13C-urea breath test at least 4 weeks after completion of treatment. The primary endpoint was eradication rates of treatments by intention- to-treat (ITT) and per-protocol (PP) analysis. Results A total of 133 patients were enrolled in the ITT and 114 in the PP analysis. The cumulative PP and ITT eradication rates were 79.7% (106/133) and 81.6% (93/114), respectively. The eradication rates were significantly higher in early eradication group than those in late eradication group in PP analysis (87.7% vs 72.1%, p=0.025). ITT analysis revealed that early eradication group achieved a higher eradication rate than late eradication group (88.9% vs 75%), but the difference was not statistically significant (p=0.089). No significant differences in compliance or adverse events were found (p=0.395 and p=0.974). Conclusions The findings suggest that early eradication therapy within 2 weeks is more effective than late eradication therapy in patients with peptic ulcer.
- Subjects
PEPTIC ulcer; HELICOBACTER pylori; BREATH tests; ADVERSE health care events
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p152
- ISSN
1976-2283
- Publication type
Article