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- Title
Effects of AST-120 on Blood Concentrations of Protein-Bound Uremic Toxins and Biomarkers of Cardiovascular Risk in Chronic Dialysis Patients.
- Authors
Lee, Chien-Te; Hsu, Chung-Yao; Tain, You-Lin; Ng, Hwee-Yeong; Cheng, Ben-Chong; Yang, Chih-Chau; Wu, Chien-Hsing; Chiou, Terry Ting-Yu; Lee, Yueh-Ting; Liao, Shang-Chih
- Abstract
Background: Removal of protein-bound uremic toxins by dialysis therapy is limited. The effect of oral adsorbent AST-120 in chronic dialysis patients has rarely been investigated. Methods: AST-120 was administered 6.0 g/day for 3 months in 69 chronic dialysis patients. The blood concentrations of indoxyl sulfate, p-cresol sulfate and biomarkers of cardiovascular risk were determined before and after AST-120 treatment. Results: AST-120 significantly decreased both the total and free forms of indoxyl sulfate and p-cresol sulfate ranging from 21.9 to 58.3%. There were significant simultaneous changes of the soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK, 24% increase), malondialdehyde (14% decrease) and interleukin-6 (19% decrease). A significant association between the decrease of indoxyl sulfate and changes of sTWEAK and interleukin-6 was noted. Conclusions: AST-120 effectively decreased indoxyl sulfate and p-cresol sulfate levels in both total and free forms. AST-120 also improved the profile of cardiovascular biomarkers. © 2014 S. Karger AG, Basel
- Subjects
KIDNEY disease treatments; CARDIOVASCULAR diseases risk factors; HEMODIALYSIS patients; CHRONIC disease treatment; UREMIA; BIOMARKERS; INTERLEUKIN-6; HEMODYNAMICS
- Publication
Blood Purification, 2014, Vol 37, Issue 1, p76
- ISSN
0253-5068
- Publication type
Article
- DOI
10.1159/000357641