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- Title
FRA3B and other common fragile sites: the weakest links.
- Authors
Huebner, Kay; Croce, Carlo M.; Huebner, K; Croce, C M
- Abstract
In 1979, the first chromosome alteration associated with familial cancer was reported. Five years later, a fragile site was observed in the same chromosome region. The product of the fragile histidine triad (FHIT) gene, which encompasses this fragile site, is partially or entirely lost in most human cancers, indicating that it has a tumour-suppressor function. Inactivation of only one FHIT allele compromises this suppressor function, indicating that a 'one-hit' mechanism of tumorigenesis is operative. Are genes disrupted at other fragile sites? And, are these genes also tumour suppressors?
- Subjects
CANCER; CHROMOSOMES; ALLELES; AMINO acids; ANIMAL experimentation; APOPTOSIS; BIOCHEMISTRY; BIOLOGICAL models; CHROMOSOME abnormalities; COMPARATIVE studies; DISEASE susceptibility; DNA; ESOPHAGEAL tumors; FORECASTING; GENE therapy; GENETICS; HYDROLASES; KIDNEY tumors; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; MICE; MOLECULAR structure; GENETIC mutation; ONCOGENES; PROTEINS; RESEARCH; GASTROINTESTINAL tumors; EVALUATION research; NEOPLASTIC cell transformation; PREVENTION
- Publication
Nature Reviews Cancer, 2001, Vol 1, Issue 3, p214
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/35106058