We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evaluation of Ribavirin Genotoxicity with Sister Chromatid Exchange and Micronuclei Assays in Humans.
- Authors
Tatar, Abdulgani; Özkurt, Zülal; Hacimüftüoglu, Ahmet; Yesilyurt, Ahmet; Vançelik, Serhat
- Abstract
Aim: The main objective of this study was to assess the genotoxicity of ribavirin in 15 patients who were suffering from Crimean-Congo haemorrhagic fever and treated with the therapy dose of the antiviral agent. Materials and Methods: Genotoxicity was evaluated using the cytokinesis-blocked micronucleus (MN) and sister chromatid exchange (SCE) assays in lymphocyte cultures that were prepared from blood samples collected from the 15 patients. The blood samples were taken on day 9 of a 10-day therapeutic regimen of ribavirin and 1 month after the cessation of therapy. Results: In all patients, the frequency of sister chromatid exchanges and the formation of micronuclei were significantly higher in the lymphocytes of blood samples that were taken in day 9 of the therapy compared to those that were collected 1 month after the cessation of therapy. In addition, on day 9, SCE and MN values were statistically different from the values of no-ribavirin control group. Conclusions: These results showed that ribavirin has a reversible genotoxic effect in humans and this effect could be due to toxic metabolites of ribavirin.
- Subjects
RIBAVIRIN; ANTI-infective agents; SISTER chromatid exchange; LYMPHOCYTES; PATIENTS; CONTROL groups
- Publication
Turkish Journal of Medical Sciences, 2009, Vol 39, Issue 2, p241
- ISSN
1300-0144
- Publication type
Article