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- Title
Regression of left ventricular hypertrophy following stenting of renal artery stenosis.
- Authors
Zeller T; Rastan A; Schwarzwälder U; Müller C; Frank U; Bürgelin K; Sixt S; Schwarz T; Noory E; Neumann F; Zeller, Thomas; Rastan, Aljoscha; Schwarzwälder, Uwe; Müller, Christian; Frank, Ulrich; Bürgelin, Karlheinz; Sixt, Sebastian; Schwarz, Thomas; Noory, Elias; Neumann, Franz-Josef
- Abstract
<bold>Purpose: </bold>To determine if angioplasty of atherosclerotic renal artery stenosis, which reduces the activation of the renin-angiotensin-aldosterone system (RAAS), may lead to regression of left ventricular hypertrophy. <bold>Methods: </bold>The study included 102 patients (58 men; mean age 67 years, range 66-69) who underwent stent-supported percutaneous transluminal renal angioplasty (PTRA) and were included in a clinical follow-up program (mean 24+/-14 months, range 6-60). As a control group, 101 contemporaneous patients (68 men; mean age 68 years, range 66-70) with essential hypertension were investigated. The primary endpoint was the change in left ventricular mass index (LVMI) determined by echocardiography. <bold>Results: </bold>Mean follow-up intervals were 24+/-14 months (range 6-60) in the study group and 27+/-14 months (range 6-60) in the controls (p = 0.09). LVMI decreased significantly by -10+/-26 g/m(2) in the study group, while it increased significantly by 9+/-28 g/m(2) in the control group (p = 0.001 between groups). In the study group, mean arterial blood pressure was significantly reduced from 99+/-11 mmHg to 90+/-11 mmHg (p<0.0001) during follow-up despite a significant reduction in medication, whereas it increased significantly from 102+/-11 mmHg to 105+/-11 mmHg (p = 0.008) in the control group, although medication was significantly increased. After adjustment for various factors and covariables, PTRA prevailed as an independent predictor for regression of LVMI (p = 0.038). <bold>Conclusion: </bold>PTRA induces regression of LVMI that is independent of the reduction in blood pressure induced by this procedure. Reduced activity of the RAAS may account for this regression.
- Publication
Journal of Endovascular Therapy, 2007, Vol 14, Issue 2, p189
- ISSN
1526-6028
- Publication type
journal article
- DOI
10.1177/152660280701400211