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- Title
T-cell fate.
- Authors
Hedrick, Stephen M.; Sharp, Leslie L.
- Abstract
Summary: Recent studies suggest that lineage commitment steps, which occur during T-cell differentiation, follow principles in common with fate specification in simple invertebrates. Here we review T-cell development from the perspective of developmental biology. We present models for αβ vs γδ and CD4 vs CD8 lineage commitment that are consistent with previously published and newly presented experiments.
- Subjects
T cell differentiation; INVERTEBRATES; DEVELOPMENTAL biology
- Publication
Immunological Reviews, 1998, Vol 165, Issue 1, p95
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1111/j.1600-065X.1998.tb01233.x