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- Title
Long-Lasting Cognitive Abnormalities after COVID-19.
- Authors
Ferrucci, Roberta; Dini, Michelangelo; Groppo, Elisabetta; Rosci, Chiara; Reitano, Maria Rita; Bai, Francesca; Poletti, Barbara; Brugnera, Agostino; Silani, Vincenzo; D'Arminio Monforte, Antonella; Priori, Alberto
- Abstract
Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study the occurrence of cognitive abnormalities in the months following hospital discharge. We recruited 38 (aged 22–74 years; 27 males) patients hospitalized for complications of SARS-CoV-2 infection in nonintensive COVID units. Participants underwent neuropsychological testing about 5 months after hospital discharge. Of all patients, 42.1% had processing speed deficits, while 26.3% showed delayed verbal recall deficits. Twenty-one percent presented with deficits in both processing speed and verbal memory. Bivariate analysis revealed a positive correlation between the lowest arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FiO2) (P/F) ratio during hospitalization and verbal memory consolidation performance (SRT-LTS score, r = 0.404, p = 0.027), as well as a positive correlation between SpO2 levels upon hospital arrival and delayed verbal recall performance (SRT-D score, rs = 0.373, p = 0.042). Acute respiratory distress syndrome (ARDS) during hospitalization was associated with worse verbal memory performance (ARDS vs. no ARDS: SRT-LTS mean score = 30.63 ± 13.33 vs. 44.50 ± 13.16, p = 0.007; SRT-D mean score = 5.95 ± 2.56 vs. 8.10 ± 2.62, p = 0.029). Cognitive abnormalities can frequently be found in COVID-19 patients 5 months after hospital discharge. Increased fatigability, deficits of concentration and memory, and overall decreased cognitive speed months after hospital discharge can interfere with work and daily activities.
- Subjects
COVID-19; VERBAL memory; ADULT respiratory distress syndrome; HOSPITAL admission &; discharge; SARS-CoV-2; BIVARIATE analysis
- Publication
Brain Sciences (2076-3425), 2021, Vol 11, Issue 2, p235
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci11020235