We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Importance of TGFβ in Cancer and Nematode Infection and Their Interaction—Opinion.
- Authors
Maruszewska-Cheruiyot, Marta; Stear, Michael James; Machcińska, Maja; Donskow-Łysoniewska, Katarzyna
- Abstract
Historically, there has been little interaction between parasitologists and oncologists, although some helminth infections predispose to the development of tumours. In addition, both parasites and tumours need to survive immune attack. Recent research suggests that both tumours and parasites suppress the immune response to increase their chances of survival. They both co-opt the transforming growth factor beta (TGFβ) signalling pathway to modulate the immune response to their benefit. In particular, there is concern that suppression of the immune response by nematodes and their products could enhance susceptibility to tumours in both natural and artificial infections.
- Subjects
NEMATODE infections; TRANSFORMING growth factors-beta; HELMINTHIASIS; IMMUNOSUPPRESSION; HELMINTHS; PARASITES
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 11, p1572
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12111572