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- Title
From Small Peptides to Large Proteins against Alzheimer'sDisease.
- Authors
Picone, Pasquale; Sanfilippo, Tiziana; Vasto, Sonya; Baldassano, Sara; Guggino, Rossella; Nuzzo, Domenico; Bulone, Donatella; San Biagio, Pier Luigi; Muscolino, Emanuela; Monastero, Roberto; Dispenza, Clelia; Giacomazza, Daniela
- Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.
- Subjects
PEPTIDES; NEUROFIBRILLARY tangles; ALZHEIMER'S disease; AMYLOID plaque; PROTEINS; TAU proteins
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 10, pN.PAG
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12101344