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- Title
A potential link between obesity and neural stem cell dysfunction.
- Authors
Livesey, Frederick J.
- Abstract
Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons - effects that are associated with activation of the IKK?/NF-?B pathway - thereby exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity.
- Subjects
OBESITY risk factors; NEURAL stem cells; HYPOTHALAMUS; LABORATORY mice; NEURONS
- Publication
Nature Cell Biology, 2012, Vol 14, Issue 10, p987
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2599