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- Title
Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes.
- Authors
Tran, Paul M. H.; Dong, Fran; Kim, Eileen; Richardson, Katherine P.; Tran, Lynn K. H.; Waugh, Kathleen; Hopkins, Diane; Cummings, Richard D.; Wang, Peng George; Rewers, Marian J.; She, Jin-Xiong; Purohit, Sharad
- Abstract
Type 1 diabetes (T1D) is an autoimmune disease, characterized by the presence of autoantibodies to protein and non-protein antigens. Here we report the identification of specific anti-carbohydrate antibodies (ACAs) that are associated with pathogenesis and progression to T1D. We compare circulatory levels of ACAs against 202 glycans in a cross-sectional cohort of T1D patients (n = 278) and healthy controls (n = 298), as well as in a longitudinal cohort (n = 112). We identify 11 clusters of ACAs associated with glycan function class. Clusters enriched for aminoglycosides, blood group A and B antigens, glycolipids, ganglio-series, and O-linked glycans are associated with progression to T1D. ACAs against gentamicin and its related structures, G418 and sisomicin, are also associated with islet autoimmunity. ACAs improve discrimination of T1D status of individuals over a model with only clinical variables and are potential biomarkers for T1D. Type I diabetes is characterized by autoantibodies directed against protein or non-protein self-antigens. Here the authors profile glycan reactive anti-carbohydrate antibodies (ACA) in a longitudinal and cross-sectional childhood diabetes cohort and associate clusters of ACA with disease progression.
- Subjects
TYPE 1 diabetes; BLOOD groups; DIABETES in children; IMMUNOGLOBULINS; GLYCOMICS; AUTOANTIBODIES; GLYCANS
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-34341-2