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- Title
Total Ischemic Time as an Independent Predictor of Response to Stem Cell Therapy in Patients with ST Segment Elevation Myocardial Infarction.
- Authors
Lim, Mary; Arslan, Zekeriya; Chunyan Cai; Kim, Christopher Y.; Yong-Jian Geng; Denktas, Ali E.
- Abstract
The selection criteria for bone marrow stem cell (BMSC) therapy are not well established for ST segment elevation myocardial infarction (STEMI) patients. This investigation seeks to utilize total ischemic time (TIT), time of symptom onset to percutaneous coronary intervention (PCI), as a criterion for giving BMSC to STEMI patients. A meta-analysis and metaregression were conducted to evaluate improvement of LVEF with BMSC and its association with TIT (<6 and ≥6 hours) and baseline LVEF (<45% and ≥45%) at short (3-6 months) and long term (>6 months) follow up. At short term, BMSC allowed improvement of LVEF with prolonged TIT (6.62%, 95% CI, 2.26 to 10.98 for <45%; 6.13%, 95% CI, 2.59 to 9.67 for ≥45%). Similarly, for long term, receiving BMSC allowed significant improvement of LVEF for prolonged TIT (9.19%, 95% CI, 2.34 to 16.05 for <45%; 7.64%, 95% CI, 3.72 to 11.56 for ≥45%). Additionally, TIT was a significant predictor of LVEF improvement independent of baseline LVEF in both short (4.96%, 95% CI, 0.72 to 9.19, P = 0.02) and long term (6.24%, 95% CI, 0.46 to 12.02, P = 0.03) follow up. Consequently, BMSC therapy allows LVEF improvement in prolonged TIT and future studies for BMSC should include TIT ≥ 6 hours as an inclusion criterion.
- Subjects
MYOCARDIAL infarction diagnosis; MYOCARDIAL infarction treatment; ISCHEMIA; ELECTROCARDIOGRAPHY; STEM cell treatment; IMMUNE response
- Publication
ISRN Otolaryngology, 2014, p1
- ISSN
2090-5742
- Publication type
Article
- DOI
10.1155/2014/293967